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| Balaji,Lakshmi; Singh,Krishna Balaji; Bhaskar,Lakkakula V.K.S.. |
| The CYP1A1 gene encodes for the enzyme, aryl hydrocarbon hydroxylase, which is involved in the biotransformation of various aromatic tobacco precarcinogens. In the present study, the association between CYP1A1 gene polymorphisms (IVS1-728G > A, Thr461Asn and Ile462Val), and the risk of oral cancer, was examined among 157 patients with oral cancer and 132 age-matched controls, in a south Indian population. The strength of the association between CYP1A1 variants and oral cancer was estimated by logistic regression. It was found that Thr461Asn was not polymorphic. Both IVS1-728G > A and Ile462Val frequencies were consistent with Hardy-Weinberg equilibrium in the control group. There were no significant differences in genotype or haplotype frequencies... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: CYP1A1; Haplotypes; Allele; Oral cancer. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000300004 |
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| Gonçalves,Márcia; Cappellari,Ángelica Regina; Santos Junior,André Avelino dos; Marchi,Fernanda Olicheski de; Macchi,Fernanda Souza; Antunes,Krist Helen; Souza,Ana Paula Duarte de; Morrone,Fernanda Bueno. |
| The esophagus and mouth tumors are very frequent malignancies worldwide. Lipopolysaccharides (LPS) are capable of regulating gene expression of pro-inflammatory cytokines by binding to toll-like receptor 4 (TLR4). Recent studies show that LPS can increase the migration ability of human esophageal cancer cell line HKESC-2 by increasing its adhesion properties. However, the effect of LPS has not been tested on viability of human esophageal and oral cancer cells. This study aimed to determine the action of LPS on the cell proliferation and viability in OE19 (adenocarcinoma) and OE21 (squamous carcinoma) cell lines, representative of human esophageal cancer, and HN30 cell line, representative of human oral carcinoma. LPS was used as treatment to OE19 and OE21... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: LPS; Oral cancer; Esophageal cancer; TLR4. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100306 |
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| Felizzola,Cláudia Ronca; Stopiglia,Angelo João; Araújo,Ney Soares de. |
| In order to establish the diagnosis and prognosis of tumors of the oral cavity, a comparative study was carried out in 130 dogs considering age, sex, breed, clinical aspects, exfoliative cytology as well as histopathology. Exfoliative cytology revealed: 100% negative for benign non-odontogenic tumors, 97.91% negative benign odontogenic tumors and 77.92% positive for malignant tumors. Histopathology showed: 59.23% malignant tumors (33.08% malignant melanoma, 9.23% squamous cell carcinoma, 5.38% osteosarcoma, 2.31% fibrosarcoma, 2.31% angiosarcoma, 1.54% malignant mesenchymal tumors, 1.54% malignant fibrohistiocytoma, 1.54% lymphoma, 0.77% leyomyosarcoma, 0.77%% epithelioid sarcoma and 0.77% angiofibrosarcoma); 36.92% benign odontogenic tumors (25.38%... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Oral cancer; Exfoliative cytology; Histopathology; Dogs. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84781999000300020 |
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